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Anti-IGF-1 receptor (IGF-1R) monoclonal antibodies (mAbs) were developed for clinical use in treating advanced stage cancers 22,23,24 , including Ganitumab, which remains under investigation as a combination therapy in clinical trials targeting Rhabdomyosarcoma (NCT03041701) and Ewing Sarcoma (NCT02306161), for which it recently received orphan drug status

Microbiology 171 , 001631 (2025)

The GLP-1 metabolic support category has rapidly emerged as one of the most dominant consumer health trends in decades

The "central plan" of GLP-1 RA is not limited to individual cells, but also achieves the reconstruction of whole-body energy metabolism through the neuroendocrine immune network: GLP-1 receptors are highly expressed in areas such as the hypothalamus and solitary tract nucleus of the brain, and their activation can inhibit the activity of appetite centers (such as NPY/AgRP neurons), while enhancing the transmission of satiety signals (such as POMC neurons)

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At this point further modifications catalyzed by aldehyde dehydrogenase and aldo-keto reductase allow to obtain carboxyethylmercapturic acid and 3-hydroxypropylmercapturic acid respectively, which are escreted with urine (Fig