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Cardiac effects of SGLT2 inhibitors: the sodium hypothesis
Tirzepatide typically produces noticeable weight loss within 4-8 weeks, with maximum effects occurring over 6-12 months
Their focus was on adult patients with diabetes and obesity and those who had been diagnosed with acute pancreatitis
The SURMOUNT-1 trial (Jastreboff et al., NEJM 2022) is the landmark efficacy data: tirzepatide at 15mg weekly produced 22.5% average body weight reduction over 72 weeks in adults with obesity without diabetes the highest weight reduction ever documented in a pharmaceutical trial
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Traditional calorie restriction can trigger metabolic adaptations that slow weight loss over time, which is why many people struggle to maintain results without broader support
