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Together the two catalytic sites form a pocket which has a high catalytic activity (35)

A commonly used regimen is a loading phase of 25 mg per week (subcutaneous injection) for 46 weeks, followed by a maintenance dose of around 2 mg every 12 weeks

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Trem2 has been reported to be a receptor that triggers differentiation and development of myeloid cells 36

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While this application requires further clinical investigation, some studies have shown the peptide stimulating cartilage cell proliferation and demonstrating potential benefits for osteoarthritis treatment