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This is a key planning detail for multi-month protocols where reagent freshness influences data quality

For patients seeking weight loss who request B12 injections, GPs should: Assess for genuine deficiency through appropriate blood tests rather than empirical treatment Provide education about the lack of evidence supporting B12 for weight loss in non-deficient individuals Explore underlying concerns about weight and energy levels, addressing these through appropriate channels Signpost to evidence-based resources such as NHS weight management services according to local pathways Patients should contact their GP if they experience unexplained fatigue, neurological symptoms (numbness, tingling, balance problems), or signs of anaemia (pallor, breathlessness, palpitations), as these may indicate B12 deficiency requiring investigation

Working out concentration The arithmetic is unchanged: mass over volume

194 In laboratory animals, EGCG inhibited platelet aggregation, prevented thrombus formation in injured vessels, and prolonged bleeding time

If you suspect a real deficiency, Triny will recommend a serum B12 and methylmalonic acid (MMA) test to confirm

Critical Reviews in Clinical Laboratory Sciences 58(6): 399429