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A new systematic review published in the journal eClinicalMedicine on Wednesday examined 48 studies that analyzed and predicted the outcomes of people who either had diabetes or were overweight or obese and took popular GLP-1 medications such as liraglutide (under brand names such as Victoza and Saxenda), semaglutide (under brand names such as Ozempic, Wegovy, Rybelsus) and tirzepatide (under brand names like Mounjaro and Zepbound)

Retatrutide activates three hormone receptors simultaneously GLP-1, GIP, and glucagon distinguishing it from approved single or dual agonists such as semaglutide and tirzepatide

Both medications are GLP-1 receptor agonists, but they work differently enough that it may affect your overall results

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Although both the peptides cause a greater production of growth hormone (GH), ipamorelin binds with growth hormone secretagogue receptors (GHSR) located in the hypothalamus and in peripheral organs, while sermorelin binds with growth hormone-stimulating hormone receptors (GHSHr) located in the hypothalamus only