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2025 Dec;333(Pt 1):148831

For individuals managing pernicious anaemia, this advancement represents a significant leap forward

It synthesizes data from early foundational studies to the most recent 2024 investigations into fusion peptides, examining the peptides biochemistry, its controversial but documented effects on sleep and hormones, and the regulatory challenges that currently define its status as an unauthorized substance in major jurisdictions

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Key Takeaway MOTS-c is a mitochondrial-derived peptide, which is a small molecule encoded by the mitochondrial DNA responsible for energy production in cells

Unlike single-mechanism ingredients that target just one aspect of aging skin, these compounds work through multiple pathways simultaneously, addressing collagen synthesis, wound healing, antioxidant protection, and skin barrier function all at once