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Ursodeoxycholic acid (ursodiol) is a medication that can help prevent gallstone formation during rapid weight loss
Clinical trials have included both male and female participants, with some notable observations: Metabolic differences Men typically have higher baseline metabolic rates and different fat distribution patterns, which may influence response magnitude but not optimal dosing protocols
Both telogen effluvium and unmasking of androgenic alopecia are possible
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Funding This work was supported by Japan Agency for Medical Research and Development (AMED) (23ama221520h0001 to K.S.), a Grant-in-Aid for Scientific Research (B) 20H03668, BRIDGE (programs for bridging the gap between R&D and the ideal society (Society 5.0 to RH and KS) and generating economic and social value to K.S.), the National Cancer Center Research and Development Fund (2022-A-20, 2023-J-2, NCC Biobank, and NCC Core Facility to K.S.), and the Yamagata Prefectural Government and City of Tsuruoka (HM)
Skin Pigmentation: Successfully induces significant and long-lasting skin darkening (tanning) following subcutaneous administration, peaking about a week after treatment completion
Djafarian, A
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