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Individuals with obesity and overweight tend to have more muscle mass than those with a healthy weight
Taking them together, especially at night, may amplify sleepiness and grogginess
8 ChuH.DuanY.LangS.JiangL.WangY.LlorenteC.et al (2020)
When compared with placebo, subcutaneous semaglutide for 30 weeks induced nausea in 11.4 to 20% of the semaglutide-treated patients (placebo 3.38%), vomiting in 4 to 11.5% (placebo 23%) and diarrhea in 4.5 to 11.3% (placebo 1.56%) ( In one phase 2 trial, subcutaneous and oral semaglutide were compared with each other ( versus 54%, respectively)
This is significantly more than what is typically seen with other weight loss medications
