Orlistat does not act hormonally, but by reducing fat absorption, it may impair the absorption of fat-soluble vitamins (A, D, E, and K), which play supporting roles in reproductive and general health
Across the dose groups studied (1 mg, 4 mg, 8 mg, and 12 mg weekly subcutaneous doses), nausea rates varied according to the dose administered and the speed of dose escalation
10.1073/pnas.88.3.986 Proc
10.1074/jbc.R113.461368 J
Essential metabolic can be impaired as a result of decreased mitochondrial activity brought on by low NAD+ levels
MilaniS.HerbstH.SchuppanD.GrapponeC.PellegriniG.PinzaniM.CasiniA.CalabroA.CiancioG.StefaniniF.1994Differential expression of matrix-metalloproteinase-1 and-2 genes in normal and fibrotic human liver