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A separate category, including CJC-1295 and Sermorelin, works through growth-hormone stimulation instead of appetite signaling: these peptides prompt the pituitary gland to release more of the body's own growth hormone, which supports fat metabolism and helps preserve lean muscle during a calorie deficit

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Further, microbial-derived neurotransmitters such as serotonin, acetylcholine, and norepinephrine may indirectly affect eating behaviour by altering mood [119, 127]

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Animal studies documented significant brain concentrations after oral administration, with cognitive effects comparable to subcutaneous injection

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