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To improve drug propertiessuch as stability and anticancer activityof diazeniumdiolate-based NO donors, a number of new molecules were synthesized and biologicaly evaluated 109,125,126

While the overall number of affected patients was small (0.2% versus 0.1%), the difference was statistically significant

When the MTHFR is not functioning at full capacity, thus causing a gene mutation, it increases the risk of developing autoimmunity

they can also reduce food intake and worsen nutritional deficiencies

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Napolitano et al., 2014