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First, there may be off-target effects from the systemic modulation of the FA pathway

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In contrast, the nucleus accumbens and putamen exhibit reduced activity in migraine patients, both of which are involved in the suppression of dopamine signaling, potentially leading to sustained pain and negative emotional states [40]

Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat