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As the first treatment strategy, conventional synthetic (cs) DMARDs like methotrexate, hydroxychloroquine, sulfasalazine, leflunomide, chloroquine, and gold salts should be used as soon as RA is diagnosed

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Its mechanism isnt fully understood

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doi:10.1056/NEJMoa1411892 Blackman A, Foster GD, Zammit G, et al

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rescuing cholinergic neurons from neurotoxic amyloid-beta42 with memantine

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