Semaglutide tends to be the better fit when: the goal is a 10 to 15 percent weight reduction, the patient has documented cardiovascular disease or is at high cardiovascular risk and wants the medication with the most outcomes data, cost or access constraints favor it, or the patient has tolerated single-pathway GLP-1s well in the past
Patients frequently express frustration on forums like GLP-1 non-responder Reddit when faced with months of minimal results despite adherence to treatment protocols
So that's huge
Umapathysivam MM, Lee MY, Jones KL, Annink CE, Cousins CE, Trahair LG, Rayner CK, Chapman MJ, Nauck MA, Horowitz M, Deane AM (2014) Comparative effects of prolonged and intermittent stimulation of the Glucagon-Like peptide 1 receptor on gastric emptying and Glycemia
Partners may need time to adjust to physical and behavioural changes
The drug has been approved to be taken weekly for adults with type 2 diabetes