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The up-regulated gene list contained a number of glutathione depletionresponsive genes reported previously, such as Trib3, Srxn1, Myc, Asns, Igfbp1, Txnrd1, or Hmox1, suggesting that these genes are robust mRNA biomarkers for evaluating hepatic glutathione depletion

and what was also interesting is that these differences persisted after adjustment for confounding variables

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Cureus , 16 (8)

Peroxiredoxin evolution and the regulation of hydrogen peroxide signaling