The group receiving the combined treatment experienced a 15.6% reduction in weight loss, while the groups receiving treatment with cagrilintide or semaglutide experienced an 8.1% and 5.1% reduction in body weight, respectively [2]
Mounjaro became India's highest-selling drug by value in October 2025, posting nearly Rs 100 crore in sales for the first time since its March launch
MallahSIGhorabOKAl-SalmiSAbdellatifOSTharmaratnamTIskandarMAet al
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Association between GLP-1 receptor agonists and incidence of lung cancer in treatment-nave type 2 diabetes
Additionally, GLP-1RAs facilitate the maintenance of endothelial barrier integrity, thus playing a crucial role in preventing vascular leakage.452 Endothelial cells exhibit enhanced NO production and concurrent suppression of endothelin formation, resulting in vascular smooth muscle relaxation and vasodilation mediated by the endothelium (e.g., GLP-1, exenatide, and liraglutide).453 Indeed, GLP-1RAs, including exenatide, liraglutide, and semaglutide, have been linked to the diminished expression of matrix metalloproteinases (MMPs).454,455,456 MMPs are a class of enzymes that play a crucial role in the breakdown of extracellular matrix components