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higher homocysteine concentrations have been associated with preeclampsia (28)

Therefore, strategies designed to target glutamine metabolism should consider the combined blockade of these transporters

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In vitro, TUG469 reduced 6-OHDA (6-hydroxydopamine)-induced neurotoxicity, whereas in a 6-OHDA-induced mouse model of PD, TUG469 improved motor deficits, preserved both dopaminergic fibres in the striatum and SN and reduced microgliosis and astrogliosis [66]