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(2021) The effect of N-acetylcysteine on bipolar depression: a systematic review and meta-analysis of randomized controlled trials

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Excessive mitochondrial ROS (mtROS) production can suppress immunoglobulin production via T-cell-dependent antigens 20

The inclusion criteria were (1) research/review articles on sources and generation of reactive free radicals, (2) research/review articles with experimental data on ROS-associated diseases, (3) research/review articles with experimental data on antioxidant activity, (4) research/review articles exploring the mode of action of synthetic as well as natural antioxidants

While this effect is generally beneficial for weight loss, it can sometimes exacerbate or combine with existing digestive sensitivities