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4.5 Safety profile The safety assessment of GLP-1 receptor agonists indicates a mostly gastrointestinal side effect profile, characterised by dose-dependent symptoms that are often treatable by meticulous titration (Madsbad 2016)

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176 Mice lacking RNF5 exhibit attenuated UPR activation, which coincides with the upregulation of inflammasome components, concomitant with the downregulation of antimicrobial peptides in intestinal epithelial cells

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