ELIXA trial included patients with recent cardiovascular event (patients with acute coronary syndrome 180 days before randomization), and although there was no benefit in MACE reduction in lixisenatide treated patients compared to placebo, results revealed cardiovascular safety of lixisenatide in this specific high risk population ( Dose-dependent effect for oral semaglutide was assessed and proven in Japanese PIONEER 9 trial, where greater reduction of HbA1c and weight loss was achieved with higher dose of oral semaglutide compared to placebo and 0.9 mg liraglutide ( Mechanisms related to cardiovascular effects of GLP-1 receptor agonists The cardiovascular effects of GLP-1 receptor agonists in CVOTs can be attributed to several mechanisms
These side effects are typically mild and improve over time
Rev Invest Clin
J Tehran Univ Heart Center 10(2):74 DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, OKeefe JH, Elsevier Ltd (2013) L-Carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis
It shares many of the same side effects as Ozempic, including persistent nausea, gastrointestinal discomfort, and potential risks to gallbladder health
1a,b and Supplementary Table 6)