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Longer-term studies of semaglutide (the active ingredient in Ozempic) show that the majority of weight loss typically occurs during the first year or so of treatment

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The underlying structure remains human

A Mayo Clinic study updated in 2026 found that postmenopausal women using HRT lost 35% more weight with tirzepatide than those not on HRT, proving that addressing the hormonal deficit is the foundation for success