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Mechanistic exploration suggested that pamidronate and clodronate markedly inhibit IGF-1-induced HIF-1 protein accumulation and VEGF expression in breast cancer cells via the PI-3K/AKT/mTOR signaling pathway and ultimately eliminate IGF-1-induced tumor angiogenesis in vivo and in vitro (38)
Detection limit and transitions used in this study are described in Supplementary Table 1
Richert, S., Bloom, E
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Do not use this drug if you or a family member has had: Medullary Thyroid Carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) FDA Adverse Event Reporting To report side effects, visit www.fda.gov/medwatch or call 1-800-FDA-1088
