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Fasting glucose typically drops 2040 mg/dL within 4 weeks, while hemoglobin A1C falls by 12% over 3 months depending on baseline severity
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Dual agonists (e.g., Tirzepatide): Act on both GLP-1 and GIP receptors to more vigorously improve blood sugar control and weight loss
Summary Upfront combination therapy with both SGLT-2 inhibitors and GLP-1 receptor agonists could further reduce cardiovascular risk in people with type 2 diabetes, although it is crucial to pare down cost and disparities to access to maximise widespread benefits at population level
The timing is the strongest clue
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