Resistance training works by: Activating mTOR pathways: Mechanical tension from lifting triggers molecular pathways that promote muscle protein synthesis, counteracting the catabolic environment of caloric restriction Increasing insulin sensitivity: Muscle contractions enhance glucose uptake independent of insulin, improving metabolic health markers Stimulating anabolic hormones: Resistance exercise acutely increases growth hormone and testosterone, both protective against muscle loss Maintaining neuromuscular efficiency: Regular lifting preserves the brain-muscle connection, preventing the rapid strength losses seen with detraining The dose-response relationship is clear: 2 sessions weekly provides significant benefit, 3 sessions provide optimal results for most people, and 4+ sessions offer marginal additional gains for advanced trainees
Bafadhel M, Singapuri A, Terry S, et al
If side effects lead to discontinuation, follow-up should address hydration, nutrition, glucose control, and alternative plans
This is where LeanPaws comes in
Curr Mol Pharmacol
Disproportionate Visceral Fat Reduction Tirzepatide reduces visceral adipose tissue beyond what total weight loss data would predict a metabolically significant effect because VAT is the primary driver of insulin resistance, cardiometabolic risk, and the inflammatory burden of obesity
