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GSTs also show thiol transferase activity and have a role in thiolysis and isomerization reactions 1
The biomarker changes (lower blood pressure, better lipid profile) are favourable and create a reasonable prior expectation, but the dedicated cardiovascular outcomes trial (TRIUMPH-Outcomes) is not expected to report until late 2027 or early 2028
Understanding these metabolic adaptations has implications for developing targeted therapies for cancer, where such metabolic vulnerabilities might be exploited for therapeutic benefit
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Raes G, Brys L, Dahal BK, Brandt J, Grooten J, Brombacher F, et al
