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Novo Nordisk is developing higher-dose oral semaglutide (25 mg and 50 mg) for obesity

Even when injected systemically into abdominal fat, the peptide appears to concentrate at injury sites

Additionally, melanocortins such as -melanocyte-stimulating hormone (-MSH), produced by both keratinocytes and melanocytes, activate the melanocortin-1 receptor (MC1R) on melanocytes, further enhancing their antioxidant capacity

For that reason, the upper arm is usually a better site when a trained caregiver or clinician is administering the injection

The experience with Zepbound's launch is instructive: despite competitive pricing, many plans took 6 to 12 months to add it to preferred formularies

Note the transit time