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Intracellular ROS elevated by concurrent inhibition of the Nrf2 and CD44v9 pathways promotes p38 MAPK activation and modulates the expression or activity of cell cycle regulators, including cyclin D1, the cyclin-dependent kinase inhibitors (CDKI

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Prx1 Cys83 binds to cullin-3, a ubiquitin ligase modulating Nrf2 ubiquitination [150] , and thereby inhibits degradation of Nrf2 allowing transcription of anti-ferroptotic enzymes [149]

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