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When APAP is combined with IFN-, it significantly altered the transcription profile of hepatocytes, including the upregulation of genes associated with cell differentiation and the reduction of interferon-inducible genes ( Ifit-3 , Isg-15 , Oasl1 , and Zbp1 ), indicating that there may be complex interactions between APAP and IFN- [238]
A future randomized, double-blind, placebo-controlled trial should study treatment of hyperpigmentation with glutathione using oral dispersible HPC film, with longer-term follow-up and larger sample size
