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Does receptor balance matter?comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models

The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]

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10.3389/fncel.2023.1156829 40 LeeY

Elevated IGF-1 signaling supports muscle protein synthesis during concurrent lipolytic activity