Consequently, many GSH-responsive nanoplatforms are designed either to deplete GSH by targeting these pathways or to exploit high GSH levels as triggers for selective drug release
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A previous study (3) underscored the crucial involvement of GSH in diverse cellular processes, including immunological function, cell proliferation, differentiation and programmed cell death
Beyond cancer, PRODH dysfunction is also linked to neuropsychiatric and metabolic diseases, including schizophrenia 65,66 , and hyperprolinemia type I 67 , reflecting its broader role in regulating mitochondrial redox balance and prolineglutamate neurotransmitter metabolism
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Via the incretin pathway, they stimulate insulin release, suppress glucagon release, slow down gastric emptying, and enhance central satiety signal