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The TPADO is capable of converting TPA into 1,2-dihydroxy-3,5-cyclohexadiene-1,4-dicarboxylate, which would be further converted into protocatechuic acid (PCA) catalyzed by DCDDH

8 The intracellular content of NADP(H) differs markedly among tissues and cell types

Mutagenesis 2006

Adropin carried by reactive oxygen species-responsive nanocapsules ameliorates renal lipid toxicity in diabetic mice

They demonstrated that a three-week supplementation of 1000 mg NR per day increased muscle NAD + metabolome, specifically NAAD and products of NAM clearance pathways, yet NAD + levels were not altered