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Hypotheses include medication-related blood pressure changes, volume depletion from gastrointestinal effects, rapid glycemic improvement leading to transient vascular dysregulation, and altered autoregulation of optic nerve head perfusion
The half-maximal inhibitory concentration (IC50) values in the GCLC enzymatic assays were determined using the XLfit software 5.4.0.8 (IDBS, Guildford, UK) or GraphPad Prism v5.01 (GraphPad Software, Inc., La Jolla, CA, USA)
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