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To further explore whether this dimerization process is a substrate-induced effect, we co-expressed another substrate ETS2, with the DDD-Ube2e2-COP1 complex and visualized the resulting assembly (Supplementary Fig

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Van Cauter E, Plat L

Although primarily indicated for diabetes management, it has shown promising results in clinical trials for weight loss in obese or overweight individuals

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Originally developed for the treatment of type 2 diabetes, they have been approved by the FDA for weight management in adults with obesity or overweight conditions with related health issues