Drug Targ
Loading phase: Initial protocols often use 2-2.5mg twice weekly for 4-6 weeks
Biomed Res Int 2015:953241 Mason C, Xiao L, Imayama I, Duggan CR, Bain C, Foster-Schubert KE et al (2011) Effects of weight loss on serum vitamin D in postmenopausal women
A BMI of 30 to 34.9, or 27.5 to 32.4 for people of Asian, Chinese, Middle Eastern, Black African or African-Caribbean origin, who meet other criteria to be treated by a specialist weight management service
Conclusion: Under tightly controlled dietary conditions, a single dose of pomegranate extract did not reduce post-OCC TMAO responses in the overall cohort
The ceiling dose is 1.0mg daily exceeding this provides no proportional increase in melanogenesis but significantly increases off-target melanocortin receptor activation