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In further research, it was found that berberine achieved antioxidant effects by reducing the expression of pro-inflammatory factors, apoptotic factors and nuclear transcription factor B (NF-b), as well as up-regulating the expression of peroxlsome proliferator-activated receptor- coactlvator-1 (PGC-1) and manganese superoxide dismutase

10.1038/srep17316 92 LangE.ZelenakC.EberhardM.BissingerR.RotteA.GhashghaeiniaM.et al (2015b)

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Desire, arousal, mood, stress, and brain signaling all play major roles

Front Med (Lausanne) (2022) 9:874916