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Having food in your system may help buffer some gastrointestinal effects

Pre-Blend Reconstitution Math (12.5/2.5 mg, 15 mg total) Metric Blend composition Value 12.5 mg retatrutide + 2.5 mg cagrilintide Metric BAC water added Value 2.5 mL Metric Concentration Value 5.0 mg/mL retatrutide + 1.0 mg/mL cagrilintide Metric Ratio held constant Value 5:1 (reta : cag) What Each Draw Delivers (12.5/2.5 mg Pre-Blend) Draw Volume 0.20 mL Units 20 units Retatrutide 1.0 mg Cagrilintide 0.2 mg Draw Volume 0.40 mL Units 40 units Retatrutide 2.0 mg Cagrilintide 0.4 mg Draw Volume 0.60 mL Units 60 units Retatrutide 3.0 mg Cagrilintide 0.6 mg Draw Volume 0.80 mL Units 80 units Retatrutide 4.0 mg Cagrilintide 0.8 mg Draw Volume 1.20 mL Units 120 units* Retatrutide 6.0 mg Cagrilintide 1.2 mg Draw Volume 1.60 mL Units 160 units* Retatrutide 8.0 mg Cagrilintide 1.6 mg Draw Volume 2.40 mL Units 240 units* Retatrutide 12.0 mg Cagrilintide 2.4 mg * Volumes above 100 units exceed a standard 1 mL insulin syringe - split into two injections or use a larger syringe

Retrieved 13 August 2012

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Participants Eligibility criteria for participating in the study were: Septic ICU resident patients (diagnosed by sepsis-3 criteria), older than 18 years, having provided written informed consent, and being nourished enterally

Acknowledgements This investigation was funded in part by the National Institutes of Health through grants R01 NS055095 (RAG) and in a facility constructed with support from Research Facilities Improvement Program Grant C06 RR15482 from the National Center for Research Resources, NIH