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Primary hepatocytes, isolated from normal rat livers, treated with H 2 O 2 (200 nM) for 24 h, were simultaneously administered with IGF-1 (100 ng/ml) for 1 and 24 h

This multi-dimensional interaction involves metabolic reprogramming, immune microenvironment, organelle crosstalk, and epigenetic regulation of gene expression, ultimately promoting vascular remodeling and collectively driving the pathological process of PH (Ranasinghe et al., 2023)

doi: 10.1016/j.juro.2012.11.173 142 OCallaghanJMMorganRDKnightSRMorrisPJ

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Combination skin finds a better overall balance