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By lowering plasma glucose through renal excretion and modestly increasing circulating ketone availability, SGLT2 inhibitors shift systemic and cerebral energy metabolism away from exclusive dependence on glucose [27]
Gastroenterology (2008) 135(6):19932002
10.1111/adb.12376 51 SalinasC
Individuals with low cardiac Pgrmc1 expression may be more susceptible to mitochondrial damage and the progression to HF
In the placebo subjects, the observed decrease was only 5.1 and 20.5%, respectively
Tamoxifen-inducible cellspecific Glp-1r KO (MIP-Cre-hGlp-1r) mice were generated in-house from our colony
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