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subcutaneous fat depot responses Regional Specificity: Investigation of preferential effects on specific adipose depots Metabolic Outcomes: Examination of metabolic improvements associated with body composition changes Laboratory protocols assess body composition using DEXA, MRI, or tissue weighing with correlation to metabolic parameters

alternative protocols (e.g., 100 mcg every other day) may be selected based on clinical response and laboratory indices

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Macrophage function in adipose tissue homeostasis and metabolic inflammation