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NASH/Liver Disease Active Research SYNERGY-NASH Phase 2 showed 80.1% relative reduction in liver fat at highest dose, and 26% NASH resolution rate with no worsening fibrosis, the highest rate reported for a pharmacological agent at time of reporting

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Insulin secretion is stimulated, glucagon and gastric acid secretion are inhibited, and GI transit and motility are decreased by incretin hormones, especially glucagon-like peptide-1 (GLP-1), which is released postprandially from L-cells lining the gut in response to food ingestion ( in vitro and in vivo , GLP-1 has been frequently demonstrated to reduce GI muscle activity via nerve-mediated mechanisms reliant on nitric oxide ( GLP-1 receptors, which are expressed in the central nervous system (CNS) in addition to peripheral tissues, are limited to neurons in the caudal nucleus of the solitary tract (NTS) and the ventrolateral medulla in the brainstem and hypothalamus ( Constipation-predominant IBS was linked to lower mucosal expression of GLP-1 receptors and serum GLP-1 concentrations (32)

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UV radiation triggers additional melanin distribution and darkening in the visible skin layers

Our patients from Hurricane to Mesquite, NV frequently notice better energy, mood, and mobility within weeks