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While IGF-1 has insulin-agonistic actions and has been used for treatment of severe insulin resistance, IGF-1 reduction with the GH antagonist pegvisomant improves glycemic control in acromegalic patients with diabetes or impaired glucose tolerance despite elevated GH (35, 36)

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[16] [17] In a 2006 controlled trial of dysthymic patients, ALCAR was found non-inferior to amisulpride for symptom relief

Kern HL, Zolot SL

Other GLP-1 medications, such as Ozempic (semaglutide) and Mounjaro (tirzepatide), are approved for diabetes but used off-label to help patients lose weight