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The siRNA-NP targeting diverse molecular mechanisms implicated in Alzheimer's disease, to downregulate genes such as bridging integrator 1 (BIN1), sortilin-related receptor 1 (SORL1), and clusterin (CLU) has proven useful in various animal models (105)

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[154] [155] Additionally, it is associated with genetic eye disorders like Cone-Rod Dystrophy and Stargardt Disease