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It is estimated that clinical trials evaluating liver-related events in patients with MASLD and compensated or decompensated cirrhosis would require a minimum recruitment of 2,886 patients with at least four years of follow-up and 1,602 patients with at least two years of follow-up, respectively

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JAMA 323 (8), 764785

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Nausea, vomiting, constipation, and appetite suppression occur across the class, though timing and severity vary between people