Additionally, Vitamin C plays a crucial role in maintaining glutathione in its active, reduced state, while adequate levels of B-vitamins (particularly unmethylated B12 and folate) are necessary to support the methylation cycle that drives natural glutathione production
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Glutathione directly neutralizes reactive oxygen species, detoxifies harmful compounds, recycles other antioxidants like vitamins C and E, and regulates critical cellular processes including DNA synthesis and cell death
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Third, over 50% of individuals with symptomatic B deficiency test negative for IF or parietal cell auto-antibodies, and the true prevalence of AIG in the UK is not known, as individuals with B deficiency rarely undergo endoscopy