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The highest caution is usually needed in patients who already have moderate to severe retinopathy , diabetic macular edema, or recent unstable retinal disease
doi: 10.1371/journal.pone.0038438 [Crossref] [ Google Scholar] BonDurant LD, Ameka M, Naber MC, Markan KR, Idiga SO, Acevedo MR, et al
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The more complex synthesis process for the arginate salt typically makes it a more expensive compound
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