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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
Additional work has proposed a possible connection to lipase activity, which could influence fat storage dynamics
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Stress and long work hours made recovery challenging
It also ramps up your metabolism, which allows you to burn more calories and lose weight
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