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Glp1r fl/fl mice treated with mGIPR-Ab/P1 also had lower total fat and inguinal WAT weights compared to vehicle, whereas Glp1r Wnt1/ mice treated with mGIPR-Ab/P1 showed no significant differences (Fig

And they don't have the GIP part of it

The proton-motive force created by the ETC is also used for many additional mitochondrial processes, especially those related with transport across the IMM ( Although the primary function of mitochondria is to generate ATP as an energy molecule required for countless cell functions, a small fraction of electrons from the ETC are transferred directly to O 2 , resulting in the generation of the superoxide anion, which can give rise to other ROS as well as reactive nitrogen species (RNS)

More specifically, tirzepatide is an agonist of both the glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP1) receptors

Toxicology and Applied Pharmacology

Where sex differences genuinely matter is in what happens on actual GLP-1 medications