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An analysis of 30,239 members showed that members in the top engagement quartile (top 25% of app opens) stayed on the program more than twice as long (2.2x more months), on average, compared to those in the bottom 25% of app opens

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doi: 10.3390/molecules201219800 101

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they may originate from mature melanocytes residing in the basal cell layer of the epithelium that have undergone some cytogenetic alterations culminating in their dedifferentiation into naevomelanocytes or they may originate from stem/progenitor melanocytes that have undergone cytogenetic alteration in the process of replacing mature melanocytes in the epithelium lost to mechanical, thermal, or chemical injury or as a result of apoptotic processes