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Many of the developmental observations were made decades ago, but their full importance can only now be understood after the realization in the living rodent and human brain of the huge glutamineglutamate (GABA) cycle flux determined in the brain in vivo and described below

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Ann Neurol

siRNA experiments GSTO1 siRNA (Trilencer-27) and scrambled control siRNA were purchased from Origene (Rockville, MD)