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Ma, etal, 2011

The four lead compounds also showed potency to overcome cholesterol transport defects in NPC1 patient fibroblasts that lack the NPC1 protein or express the common NPC1 I1061T mutation, which is still functional but only present in low amounts in LE/Lys [5, 6]

this phenomenon is also known as oxidative stress

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That said, its not FDA-approved for dogs, so it should only be used under veterinary supervision